Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia.

ABSTRACT: Preterm birth is a leading cause of long-term motor and cognitive deficits. Clinical studies suggest that some of these deficits result from disruption of cerebellar development, but the mechanisms that mediate cerebellar abnormalities in preterm infants are largely unknown. Furthermore, it remains unclear whether preterm birth and precocious exposure to the ex-utero environment directly disrupt cerebellar development or indirectly by increasing the probability of cerebellar injury, including that resulting from clinical interventions and protocols associated with the care of preterm infants. In this study, we analyzed the cerebellum of preterm pigs delivered via c-section at 91% term and raised for 10 days, until term-equivalent age. The pigs did not receive any treatments known or suspec

SUBMITTER: Iskusnykh IY 

PROVIDER: S-EPMC6291230 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature