Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease.

ABSTRACT:

Background

Constipation is a prodromal feature of Parkinson's disease (PD) and the gastrointestinal (GI) tract is implicated in the pathogenesis of PD. However, no studies have demonstrated ante-mortem relationships between nigrostriatal dysfunction and GI dysautonomia in PD.

Methods

The Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT) assesses dysautonomia in the multi-center Parkinson's Progression Marker Initiative (PPMI). We used linear mixed-effects models and reliable change indices (RCIs) to examine longitudinal associations between dysautonomia and dopamine transporter (DAT) striatal binding ratios (SBRs) measured by single-photon emission computerized tomography in PPMI participants over four years (n = 397 at baseline).

Results

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SUBMITTER: Hinkle JT 

PROVIDER: S-EPMC6291234 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature