Removal of hyperpolarized ¹²⁹ Xe gas-phase contamination in spectroscopic imaging of the lungs.

ABSTRACT:

Purpose

A novel technique is presented for retrospective estimation and removal of gas-phase hyperpolarized Xenon-129 (HP ¹²⁹ Xe) from images of HP ¹²⁹ Xe dissolved in the barrier (comprised of parenchymal lung tissue and blood plasma) and red blood cell (RBC) phases. The primary aim is mitigating RF pulse performance limitations on measures of gas exchange (e.g., barrier-gas and RBC-gas ratios). Correction for gas contamination would simplify technical dissemination of HP ¹²⁹ Xe applications across sites with varying hardware performance, scanner vendors, and models.

Methods

Digital lung phantom and human subject experiments (N = 8 healthy; N = 1 with idiopathic pulmonary fibrosis) were acquired with 3D radial trajectory and 1-point Dixon sp

SUBMITTER: Hahn AD 

PROVIDER: S-EPMC6291357 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature