Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis.

ABSTRACT: Sepsis is one of the main causes of mortality in hospitalized patients. Despite the recent technical advances and the development of novel generation of antibiotics, severe sepsis remains a major clinical and scientific challenge in modern medicine. Unsuccessful efforts have been dedicated to the search of therapeutic options to treat the deleterious inflammatory components of sepsis. Recent findings on neuronal networks controlling immunity raised expectations for novel therapeutic strategies to promote the regulation of sterile inflammation, such as autoimmune diseases. Interesting studies have dissected the anatomical constituents of the so-called "cholinergic anti-inflammatory pathway", suggesting that electrical vagus nerve stimulation and pharmacological activation of beta-2 adrenerg

SUBMITTER: Kanashiro A 

PROVIDER: S-EPMC6291365 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature