Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae.

ABSTRACT: Chitinases and chitinase-like proteins are an evolutionary conserved group of proteins. In the absence of chitin synthesis in mammals, the conserved presence of chitinases suggests their roles in physiology and immunity, but experimental evidence to prove these roles is scarce. Chitotriosidase (chit1) is one of the two true chitinases present in mammals and the most prevalent chitinase in humans. In this study, we investigated the regulation and the role of chit1 in a mouse model of Klebsiella pneumoniae lung infection. We show that chitinase activity in bronchoalveolar lavage fluid is significantly reduced during K. pneumoniae lung infection. This reduced activity is inversely correlated with the number of neutrophils. Further, instilling neutrophil lysates in lungs decrease

SUBMITTER: Sharma L 

PROVIDER: S-EPMC6291403 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature