First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist ⁶⁸Ga-NODAGA-MJ9.

ABSTRACT:

Background

Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of ⁶⁸Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection. To be used as input in OLINDA/EXM 2.0, time-integrated activity coefficients were derived from manually drawn regions of interest over the following body regions: brain, thyroid, lungs, heart, liver, gallbladder, spleen, stomach, kidneys, adrenals, red marrow,

SUBMITTER: Gnesin S 

PROVIDER: S-EPMC6291411 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature