Whole-body MRI for staging and interim response monitoring in paediatric and adolescent Hodgkin's lymphoma: a comparison with multi-modality reference standard including ¹⁸F-FDG-PET-CT.

ABSTRACT:

Objectives

To prospectively investigate concordance between whole-body MRI (WB-MRI) and a composite reference standard for initial staging and interim response evaluation in paediatric and adolescent Hodgkin's lymphoma.

Methods

Fifty patients (32 male, age range 6-19 years) underwent WB-MRI and standard investigations, including ¹⁸F-FDG-PET-CT at diagnosis and following 2-3 chemotherapy cycles. Two radiologists in consensus interpreted WB-MRI using prespecified definitions of disease positivity. A third radiologist reviewed a subset of staging WB-MRIs (n = 38) separately to test for interobserver agreement. A multidisciplinary team derived a primary reference standard using all available imaging/clinical investigations. Subsequently, a second multidisciplinary pan

SUBMITTER: Latifoltojar A 

PROVIDER: S-EPMC6291431 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature