Processing of the Terminal Alpha-1,2-Linked Mannose Residues From Oligomannosidic <i>N</i>-Glycans Is Critical for Proper Root Growth.

ABSTRACT: N-glycosylation is an essential protein modification that plays roles in many diverse biological processes including protein folding, quality control and protein interactions. Despite recent advances in characterization of the N-glycosylation and N-glycan processing machinery our understanding of N-glycosylation related processes in plant development is limited. In Arabidopsis thaliana, failure of mannose trimming from oligomannosidic N-glycans in the endoplasmic reticulum (ER) and cis/medial-Golgi leads to a defect in root development in the mns123 triple mutant. Here, we show that the severe root phenotype of mns123 is restored in asparagine-linked glycosylation (ALG)-deficient plants with distinct defects in the biosynthesis

SUBMITTER: Veit C 

PROVIDER: S-EPMC6291467 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature