Vestibulospinal and Corticospinal Modulation of Lumbosacral Network Excitability in Human Subjects.

ABSTRACT: As part of a project aimed to develop a novel, non-invasive techniques for comprehensive assessment of supraspinal-spinal connectivity in humans, the present study sought to explore the convergence of descending vestibulospinal and corticospinal pathways onto lumbosacral motor pools. Transcutaneous electrical spinal stimulation-evoked motor potentials were recorded from knee and ankle flexors and extensors in resting neurologically intact participants. Descending influences on lumbosacral motor neurons were studied using galvanic vestibular (GVS) or transcranial magnetic stimulation (TMS) to elicit descending vestibulospinal or corticospinal volleys, respectively. Facilitatory conditioning effects of descending corticospinal volleys were manifested by a significant increase of spinally evo

SUBMITTER: Sayenko DG 

PROVIDER: S-EPMC6291495 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature