Pharmacokinetics of sodium thiosulfate in Guinea pig perilymph following middle ear application.

ABSTRACT:

Hypothesis

To determine the pharmacokinetics of sodium thiosulfate in the inner ear perilymph following middle ear application in Guinea pigs.

Background

Cisplatin chemotherapy is often associated with a dose-dependent high frequency sensorineural hearing loss. Sodium thiosulfate has been shown to reduce cisplatin-induced ototoxicity when given intravenously, but this may limit the tumoricidal effects of the chemotherapy. Recent animal studies looking at middle ear application of sodium thiosulfate have shown prevention of outer hair cell and hearing loss, but the perilymph pharmacokinetics have not yet been established.

Methods

Twenty Guinea pig ears were split into two groups and administered sodium thiosulfate to the middle ear at either a concentration of 250 mg/m

SUBMITTER: Schroeder RJ 

PROVIDER: S-EPMC6291635 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature