HGF-mediated S100A11 overexpression enhances proliferation and invasion of gastric cancer.

ABSTRACT: S100 proteins are a group of low molecular weight (10-12 kDa) acidic proteins belonging to the largest family of EFhand calciumbinding proteins. S100A11, also known as S100C or calgizzarin, is an important member of the S100 family. S100A11 overexpression has been reported in a number of cancers including papillary thyroid carcinoma, colon, pancreatic, and breast cancer. One other study demonstrated that increased S100A11 expression is correlated with gastric cancer metastasis and poor overall disease prognosis. This study aimed to identify the function of S100A11 associated with cell proliferation and invasion in gastric cancer. We used cell culture, western blotting, reverse transcription-polymerase chain reaction, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and S

SUBMITTER: Koh SA 

PROVIDER: S-EPMC6291695 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature