Addicted to sugar: roles of glycans in the order Mononegavirales.

ABSTRACT: Glycosylation is a biologically important protein modification process by which a carbohydrate chain is enzymatically added to a protein at a specific amino acid residue. This process plays roles in many cellular functions, including intracellular trafficking, cell-cell signaling, protein folding and receptor binding. While glycosylation is a common host cell process, it is utilized by many pathogens as well. Protein glycosylation is widely employed by viruses for both host invasion and evasion of host immune responses. Thus better understanding of viral glycosylation functions has potential applications for improved antiviral therapeutic and vaccine development. Here, we summarize our current knowledge on the broad biological functions of glycans for the Mononegavirales, an order of envel

SUBMITTER: Ortega V 

PROVIDER: S-EPMC6291800 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature