Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease.

ABSTRACT:

Background

Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis to detect variants contributing to both traits.

Methods

We performed a bivariate GWAS to discover novel loci associated with both heart disease, using a CAD meta-analysis (122 733 cases and 424 528 controls), and lipid traits, using results from the Global Lipid Genetics Consortium (188 577 subjects).

Results

We identified six previously unreported loci at genome-wide significance ( P<5×10^-8), three which were associated with triglycerides and CAD, two which were

SUBMITTER: Siewert KM 

PROVIDER: S-EPMC6291836 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature