The dawn of precision medicine in HIV: state of the art of pharmacotherapy.

ABSTRACT:

Introduction

Combination antiretroviral therapy (ART) reduces viral load to under the limit of detection, successfully decreasing HIV-related morbidity and mortality. Due to viral mutations, complex drug combinations and different patient response, there is an increasing demand for individualized treatment options for patients.

Areas covered

This review first summarizes the pharmacokinetic and pharmacodynamic profile of clinical first-line drugs, which serves as guidance for antiretroviral precision medicine. Factors which have influential effects on drug efficacy and thus precision medicine are discussed: patients' pharmacogenetic information, virus mutations, comorbidities, and immune recovery. Furthermore, strategies to improve the application of precision medicine are di

SUBMITTER: Mu Y 

PROVIDER: S-EPMC6291855 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature