Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer's disease.

ABSTRACT:

Background

The roles of the choroid plexus (CP) and cerebrospinal fluid (CSF) production have drawn increasing attention in Alzheimer's disease (AD) research. Specifically, studies document markedly decreased CSF production and turnover in moderate-to-severe AD. Moreover, reduced CP function and CSF turnover lead to impaired clearance of toxic metabolites, likely promote neuroinflammation, and may facilitate neuronal death during AD progression. We analyzed CP gene expression in AD compared with control subjects, specifically considering those genes involved with CSF production and CP structural integrity.

Methods

The Brown-Merck Gene Expression Omnibus (GEO) database (CP transcripts) was mined to examine changes in gene expression in AD compared to controls with a focus on

SUBMITTER: Kant S 

PROVIDER: S-EPMC6291926 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature