Antimicrobial exposure and the risk of delirium in critically ill patients.

ABSTRACT:

Background

Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential associations with the daily risk of delirium after critical illness is adjusted for.

Methods

Our study was a nested cohort that enrolled non-neurological critically ill adults from a medical or surgical intensive care unit (ICU) with daily follow-up to 30 days. Our independent variable was exposure to previous-day antimicrobial class: beta-lactams (subclasses: penicillins, first- to third-generation cephalosporins, fourth-generation cephalosporins, and carbapenems), macrolides, fluoroquinolones, and other. We adjusted for baseline c

SUBMITTER: Grahl JJ 

PROVIDER: S-EPMC6291937 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature