Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota.

ABSTRACT:

Background

Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host.

Results

The oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails. The antibiotic-altered gut microbiota directly influenced the increased pesticide bioavailability through downregulating hepatic metabolic enzyme gene expre

SUBMITTER: Zhan J 

PROVIDER: S-EPMC6291969 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature