Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes.

ABSTRACT:

Background

For the success of the malaria control and eradication programme it is essential to reduce parasite transmission by mosquito vectors. In the midguts of mosquitoes fed with parasite-infected blood, sexual-stage parasites fertilize to develop into motile ookinetes that traverse midgut epithelial cells and reside adjacent the basal lamina. Therefore, the ookinete is a promising target of transmission-blocking vaccines to break the parasite lifecycle in mosquito vectors. However, the molecular mechanisms of ookinete formation and invasion of epithelial cells have not been fully elucidated. A unique structure called the crystalloid body has been identified in the ookinete cytoplasm by electron microscopy, but its biological functions remain unclear.

Methods

A recombina

SUBMITTER: Jenwithisuk R 

PROVIDER: S-EPMC6291999 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature