ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) is associated with atypical fronto-subcortical neural circuitry and heightened delay discounting, or a stronger preference for smaller, immediate rewards over larger, delayed rewards. Recent evidence of ADHD-related sex differences in brain structure and function suggests anomalies in fronto-subcortical circuitry may differ among girls and boys with ADHD. The current study examined whether the functional connectivity (FC) within fronto-subcortical neural circuitry differs among girls and boys with ADHD compared to same-sex typically developing (TD) controls and relates to delay discounting.

Methods

Participants include 8-12-year-old children with ADHD (n = 72, 20 girls) and TD controls (n = 75, 21 girls). Fronto-subc

SUBMITTER: Rosch KS 

PROVIDER: S-EPMC6292003 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature