Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer.

ABSTRACT:

Background

Recent observations indicate a decreased cancer risk in patients with Alzheimer's disease (AD). AD is a severe neurodegenerative disorder characterized by progressive cognitive decline. The 8q24 region has been shown to be involved in AD aetiology. We aimed to identify and explore the potential oncogenes or antioncogenes on chromosome 8q24.

Methods

We compared expression of genes on Chromosome 8q24 in 32 pairs of samples from The Cancer Genome Atlas (TCGA) database. We conducted bioinformatics analysis of the commonly used gastric cancer databases and performed clinical verification of gastric cancer samples, combined with assessment of biological function both in vitro and in vivo to determine the relationship between upregulated expression of GRINA and gastric c

SUBMITTER: Xu DH 

PROVIDER: S-EPMC6292005 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature