Screening of Streptococcus Suis serotype 2 resistance genes with GWAS and transcriptomic microarray analysis.

ABSTRACT:

Background

Swine streptococcosis has caused great economic loss in the swine industry, and the major pathogen responsible for this disease is Streptococcus Suis serotype 2 (SS2). Disease resistance breeding is a fundamental way of resolving this problem. With the development of GWAS and transcriptomic microarray technology, we now have powerful research tools to identify SS2 resistance genes.

Results

In this research, we generated an F₂ generation of SS2 resistant C57BL/6 and SS2 susceptive A/J mice. With the F₂ generation of these two mice strains and GWAS analysis, we identified 286 significant mouse genome SNPs sites associated with the SS2 resistance trait. Gene expression profiles for C57BL/6 and A/J were analyzed under SS2 infection pressure by mi

SUBMITTER: Ma Z 

PROVIDER: S-EPMC6292034 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature