Subject level clustering using a negative binomial model for small transcriptomic studies.

ABSTRACT:

Background

Unsupervised clustering represents one of the most widely applied methods in analysis of high-throughput 'omics data. A variety of unsupervised model-based or parametric clustering methods and non-parametric clustering methods have been proposed for RNA-seq count data, most of which perform well for large samples, e.g. N ≥ 500. A common issue when analyzing limited samples of RNA-seq count data is that the data follows an over-dispersed distribution, and thus a Negative Binomial likelihood model is often used. Thus, we have developed a Negative Binomial model-based (NBMB) clustering approach for application to RNA-seq studies.

Results

We have developed a Negative Binomial Model-Based (NBMB) method to cluster samples using a stochastic version of the expectation-ma

SUBMITTER: Li Q 

PROVIDER: S-EPMC6292049 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature