Safety and effectiveness of antimalarial therapy in sickle cell disease: a systematic review and network meta-analysis.

ABSTRACT:

Background

About 80% of all reported sickle cell disease (SCD) cases in children anually are recorded in Africa. Although malaria is considered a major cause of death in SCD children, there is limited data on the safety and effectiveness of the available antimalarial drugs used for prophylaxis. Also, previous systematic reviews have not provided quantitative measures of preventive effectiveness. The purpose of this research was to conduct a systematic review and meta-analysis of the available literature to determine the safety and effectiveness of antimalarial chemoprophylaxis used in SCD patients.

Methods

We searched in PubMed, Medline, CINAHL, POPLine and Cochrane library, for the period spanning January 1990 to April 2018. We considered randomized or quasi-randomized cont

SUBMITTER: Frimpong A 

PROVIDER: S-EPMC6292161 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature