Posterior HOX genes and HOTAIR expression in the proximal and distal colon cancer pathogenesis.

ABSTRACT:

Background

Increasing evidences showed that the location of the primary tumor on the right (proximal) or left (distal) side of the colon have a prognostic/predictive value for colon cancer patients. However, the understanding of the molecular mechanisms that contribute to the pathogenesis in different location of colon is still unclear. Probably an important role could be played by genes that control the spatial-temporal development of bodily structures, such as HOX genes.

Methods

The main purpose of this study was to analyze the expression of the paralogous 13 HOX genes and of the HOX regulating lncRNA HOTAIR in distal and proximal CRC cases. We have carried out a Tissue Micro Array with left and right CRC samples associated with all clinical-pathological parameters of pati

SUBMITTER: Tatangelo F 

PROVIDER: S-EPMC6292169 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature