Circulating levels of IL-1 family cytokines and receptors in Alzheimer's disease: new markers of disease progression?

ABSTRACT:

Background

Although the mechanisms underlying AD neurodegeneration are not fully understood, it is now recognised that inflammation could play a crucial role in the initiation and progression of AD neurodegeneration. A neuro-inflammatory network, based on the anomalous activation of microglial cells, includes the production of a number of inflammatory cytokines both locally and systemically. These may serve as diagnostic markers or therapeutic targets for AD neurodegeneration.

Methods

We have measured the levels of the inflammation-related cytokines and receptors of the IL-1 family in serum of subjects with AD, compared to mild cognitive impairment (MCI), subjective memory complaints (SMC), and normal healthy subjects (NHS). Using a custom-made multiplex ELISA array, we exam

SUBMITTER: Italiani P 

PROVIDER: S-EPMC6292179 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature