Neurofilament light chain serum levels correlate with 10-year MRI outcomes in multiple sclerosis.

ABSTRACT:

Objective

To assess the value of annual serum neurofilament light (NfL) measures in predicting 10-year clinical and MRI outcomes in multiple sclerosis (MS).

Methods

We identified patients in our center's Comprehensive Longitudinal Investigations in MS at Brigham and Women's Hospital (CLIMB) study enrolled within 5 years of disease onset, and with annual blood samples up to 10 years (n = 122). Serum NfL was measured using a single molecule array (SIMOA) assay. An automated pipeline quantified brain T2 hyperintense lesion volume (T2LV) and brain parenchymal fraction (BPF) from year 10 high-resolution 3T MRI scans. Correlations between averaged annual NfL and 10-year clinical/MRI outcomes were assessed using Spearman's correlation, univariate, and multivariate linear reg

SUBMITTER: Chitnis T 

PROVIDER: S-EPMC6292183 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature