Hippo/Mst signalling couples metabolic state and immune function of CD8α⁺ dendritic cells.

ABSTRACT: Dendritic cells orchestrate the crosstalk between innate and adaptive immunity. CD8α⁺ dendritic cells present antigens to CD8⁺ T cells and elicit cytotoxic T cell responses to viruses, bacteria and tumours ¹ . Although lineage-specific transcriptional regulators of CD8α⁺ dendritic cell development have been identified ² , the molecular pathways that selectively orchestrate CD8α⁺ dendritic cell function remain elusive. Moreover, metabolic reprogramming is important for dendritic cell development and activation^3,4, but metabolic dependence and regulation of dendritic cell subsets are largely uncharacterized. Here we use a data-driven systems biology algorithm (NetBID) to identify a role of the Hippo pathway kinases

SUBMITTER: Du X 

PROVIDER: S-EPMC6292204 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature