Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device.

ABSTRACT:

Objectives

The PediaFlow (HeartWare International, Inc, Framingham, Mass) is a miniature, implantable, rotodynamic, fully magnetically levitated, continuous-flow pediatric ventricular assist device. The fourth-generation PediaFlow was evaluated in vitro and in vivo to characterize performance and biocompatibility.

Methods

Supported by 2 National Heart, Lung, and Blood Institute contract initiatives to address the limited options available for pediatric patients with congenital or acquired cardiac disease, the PediaFlow was developed with the intent to provide chronic cardiac support for infants as small as 3 kg. The University of Pittsburgh-led Consortium evaluated fourth-generation PediaFlow prototypes both in vitro and within a preclinical ovine model (n = 11). The latter

SUBMITTER: Olia SE 

PROVIDER: S-EPMC6292205 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature