Drug-target-disease network analysis of gene-phenotype connectivity for genistein in ovarian cancer.

ABSTRACT:

Purpose

Genistein belongs to the group of isoflavones, which include powerful anticancer agents. Its antitumor properties have been intensively described in many cancers, but related studies assessing ovarian cancer are scarce. The aim of this study was to develop a new method of the underlying mechanisms of genistein's effects and broaden the perspective of targeted therapies in ovarian carcinoma.

Materials and methods

Genistein targets were searched in the DrugBank database. Prediction of drug interactions with targets (including secondary targets) was performed with STRING database. Interaction pairs with overall score above 0.9 were recorded for protein-protein interaction (PPI) network generation based on the Cytoscape software. Genes with intense interconnections were

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6292408 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature