Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures.

ABSTRACT:

Objectives

To determine whether women with surgical menopause have a higher risk of frailty than naturally menopausal women.

Design

Prospective cohort study with up to 18 years of follow-up.

Setting

Four U.S clinical centers.

Participants

Community-dwelling white women aged 65 and older (mean 71.2±5.2) enrolled in the Study of Osteoporotic Fractures (N=7,699).

Measurements

Surgical menopause was based on participant self-report of having undergone bilateral oophorectomy before menopause. The outcome was incident frailty, classified as robust, prefrail, frail, or death at 4 follow-up interviews, conducted 6 to 18 years after baseline. Information on baseline serum total testosterone concentrations was available for 541 participants.

Results

At base

SUBMITTER: Huang G 

PROVIDER: S-EPMC6292428 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature