Sickle Cell Disease: Advances in Treatment.

ABSTRACT:

Background

Sickle cell disease causes significant morbidity and mortality and affects the economic and healthcare status of many countries. Yet historically, the disease has not had commensurate outlays of funds that have been aimed at research and development of drugs and treatment procedures for other diseases.

Methods

This review examines several treatment modalities and new drugs developed since the late 1990s that have been used to improve outcomes for patients with sickle cell disease.

Results

Targeted therapies based upon the pathophysiologic mechanisms of sickle cell disease that result in organ dysfunction and painful episodes include hydroxyurea, L-glutamine, crizanlizumab, and other drugs that are currently on the market or are on the verge of becoming avai

SUBMITTER: Gardner RV 

PROVIDER: S-EPMC6292457 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature