Schistosomiasis is associated with incident HIV transmission and death in Zambia.

ABSTRACT: BACKGROUND:We examined relationships between schistosome infection, HIV transmission or acquisition, and all-cause death. METHODS:We retrospectively tested baseline sera from a heterosexual HIV-discordant couple cohort in Lusaka, Zambia with follow-up from 1994-2012 in a nested case-control design. Schistosome-specific antibody levels were measured by ELISA. Associations between baseline antibody response to schistosome antigens and incident HIV transmission, acquisition, and all-cause death stratified by gender and HIV status were assessed. In a subset of HIV- women and HIV+ men, we performed immunoblots to evaluate associations between Schistosoma haematobium or Schistosoma mansoni infection history and HIV incidence. RESULTS:Of 2,145 individuals, 59% had positive baseline schistosome-sp

SUBMITTER: Wall KM 

PROVIDER: S-EPMC6292564 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature