LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity.

ABSTRACT:

Introduction

Antibiotic-loaded poly(methyl methacrylate) bone cements (ALBCs) are widely used in total joint replacement (TJR), for local delivery of antibiotics to provide prophylaxis against prosthetic joint infections (PJI). One of the shortcomings of the current generation of ALBCs is that the antibiotic release profile is characterized by a burst over the first few hours followed by a sharp decrease in rate for the following several days (often below minimum inhibitory concentration (MIC)), and, finally, exhaustion (after, typically, ~ 20 d). This profile means that the ALBCs provide only short-term antimicrobial action against bacterial strains involved PJI.

Rationale

The purpose of the present study was to develop an improved antibiotic delivery system for an ALBC. Th

SUBMITTER: Al Thaher Y 

PROVIDER: S-EPMC6292632 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature