Chain organization of human interphase chromosome determines the spatiotemporal dynamics of chromatin loci.

ABSTRACT: We investigate spatiotemporal dynamics of human interphase chromosomes by employing a heteropolymer model that incorporates the information of human chromosomes inferred from Hi-C data. Despite considerable heterogeneities in the chromosome structures generated from our model, chromatins are organized into crumpled globules with space-filling (SF) statistics characterized by a single universal scaling exponent (ν = 1/3), and this exponent alone can offer a quantitative account of experimentally observed, many different features of chromosome dynamics. The local chromosome structures, whose scale corresponds to that of topologically associated domains (∼ 0.1 - 1 Mb), display dynamics with a fast relaxation time (≲ 1 - 10 sec); in contrast, the long-range spatial reorganization of the entire

SUBMITTER: Liu L 

PROVIDER: S-EPMC6292649 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature