Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis.

ABSTRACT:

Purpose

Perivascular adipose tissue (PVAT) surrounds the arterial adventitia and plays an important role in vascular homeostasis. PVAT expands in obesity, and inflamed PVAT can locally promote endothelial dysfunction and atherosclerosis. Here, using adipose tissue transplantation, we tested the hypothesis that expansion of PVAT can also remotely exacerbate vascular disease.

Methods

Fifty milligrams of abdominal aortic PVAT was isolated from high-fat diet (HFD)-fed wild-type mice and transplanted onto the abdominal aorta of lean LDL receptor knockout mice. Subcutaneous and visceral adipose tissues were used as controls. After HFD feeding for 10 weeks, body weight, glucose/insulin sensitivity, and lipid levels were measured. Adipocytokine gene expression was assessed in the tr

SUBMITTER: Horimatsu T 

PROVIDER: S-EPMC6292666 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature