Neonate and infant brain development from birth to 2 years assessed using MRI-based quantitative susceptibility mapping.

ABSTRACT: The human brain rapidly develops during the first two years following birth. Quantitative susceptibility mapping (QSM) provides information of iron and myelin variations. It is considered to be a valuable tool for studying brain development in early life. In the present work, QSM is performed on neonates, 1-year and 2-year old infants, as well as a group of adults for the purpose of reference. Age-specific templates representing common brain structures are built for each age group. The neonate and infant QSM templates have shown some unique findings compared to conventional T1w and T2w imaging techniques. The contrast between the gray and white matters on the QSM images did not change through brain development from neonate to adult. A linear correlation was found between brain myelination

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6292682 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature