Evolution of longevity improves immunity in <i>Drosophila</i>.

ABSTRACT: Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in lifespan and correlated fitness traits remains largely unclear. Here, we have analyzed the genomes of a set of Drosophila melanogaster lines that have been maintained under direct selection for postponed reproduction and indirect selection for longevity, relative to unselected control lines, for over 35 years. We identified many candidate loci shaped by selection for longevity and late-life fertility,

SUBMITTER: Fabian DK 

PROVIDER: S-EPMC6292704 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature