Response to Fungal Dysbiosis by Gut-Resident CX3CR1⁺ Mononuclear Phagocytes Aggravates Allergic Airway Disease.

ABSTRACT: Sensing of the gut microbiota, including fungi, regulates mucosal immunity. Whether fungal sensing in the gut can influence immunity at other body sites is unknown. Here we show that fluconazole-induced gut fungal dysbiosis has persistent effects on allergic airway disease in a house dust mite challenge model. Mice with a defined community of bacteria, but lacking intestinal fungi were not susceptible to fluconazole-induced dysbiosis, while colonization with a fungal mixture recapitulated the detrimental effects. Gut-resident mononuclear phagocytes (MNPs) expressing the fractalkine receptor CX3CR1 were essential for the effect of gut fungal dysbiosis on peripheral immunity. Depletion of CX3CR1⁺ MNPs or selective inhibition of Syk signaling downstream of fungal sensing in these c

SUBMITTER: Li X 

PROVIDER: S-EPMC6292739 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature