Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC6292739 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cell host & microbe 20181129 6
Sensing of the gut microbiota, including fungi, regulates mucosal immunity. Whether fungal sensing in the gut can influence immunity at other body sites is unknown. Here we show that fluconazole-induced gut fungal dysbiosis has persistent effects on allergic airway disease in a house dust mite challenge model. Mice with a defined community of bacteria, but lacking intestinal fungi were not susceptible to fluconazole-induced dysbiosis, while colonization with a fungal mixture recapitulated the de ...[more]