Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel.

ABSTRACT: Glioblastoma (GBM) is the most common primary malignant brain tumor, with patients exhibiting poor survival (median survival time: 15 months). Difficulties in treating GBM include not only the inability to resect the diffusively-invading tumor cells, but also therapeutic resistance. The perivascular niche (PVN) within the GBM tumor microenvironment contributes significantly to tumor cell invasion, cancer stem cell maintenance, and has been shown to protect tumor cells from radiation and chemotherapy. In this study, we examine how the inclusion of non-tumor cells in culture with tumor cells within a hydrogel impacts the overall gene expression profile of an in vitro artificial perivascular niche (PVN) comprised of endothelial and stromal cells directly cultured with GBM tumor cells within a

SUBMITTER: Ngo MT 

PROVIDER: S-EPMC6292767 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature