Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas.

ABSTRACT:

Background

Tobacco smoking creates DNA damage, inducing mutations and potentially altering the tumor immune microenvironment. These types of genetic and immune microenvironment alterations are critical factors known to affect tumor response to immunotherapy. Here we analyze the association between the mutational signature of tobacco smoking, tumor mutational load, and metrics of immune activity in squamous cell carcinomas arising in the head and neck and lung.

Methods

Using RNA and DNA sequencing data from The Cancer Genome Atlas head and neck (HNSC; n = 287) and lung (LUSC; n = 130) squamous cell carcinoma data sets and two independent gene expression data sets (HNSC, n = 136; LUSC, n = 75), we examined associations between the mutational smoking signature, mutation count,

SUBMITTER: Desrichard A 

PROVIDER: S-EPMC6292793 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature