Association Between Proportion of Nuclei With High Chromatin Entropy and Prognosis in Gynecological Cancers.

ABSTRACT:

Background

Nuclear texture analysis measuring differences in chromatin structure has provided prognostic biomarkers in several cancers. There is a need for improved cell-by-cell chromatin analysis to detect nuclei with highly disorganized chromatin. The purpose of this study was to develop a method for detecting nuclei with high chromatin entropy and to evaluate the association between the presence of such deviating nuclei and prognosis.

Methods

A new texture-based biomarker that characterizes each cancer based on the proportion of high-chromatin entropy nuclei (<25% vs ≥25%) was developed on a discovery set of 175 uterine sarcomas. The prognostic impact of this biomarker was evaluated on a validation set of 179 uterine sarcomas, as well as on independent validation sets of

SUBMITTER: Nielsen B 

PROVIDER: S-EPMC6292794 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature