Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study.

ABSTRACT:

Objectives

Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce.

Methods

In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART).

Results

A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB. Adequate initial TB treatment was provided for 8% of patients with MDR-TB compared with 80% of those with pan-susceptible TB. By twelve months, an estimated 57.3% (95%CI 41.5-74.1) of MDR-TB patients had started adequate treatment. While 67% received ART, HIV-RNA suppression was demonstrated in only 23%.

Conclusions

Our result

SUBMITTER: Efsen AMW 

PROVIDER: S-EPMC6293190 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature