Brain Age in Early Stages of Bipolar Disorders or Schizophrenia.

ABSTRACT:

Background

The greater presence of neurodevelopmental antecedants may differentiate schizophrenia from bipolar disorders (BD). Machine learning/pattern recognition allows us to estimate the biological age of the brain from structural magnetic resonance imaging scans (MRI). The discrepancy between brain and chronological age could contribute to early detection and differentiation of BD and schizophrenia.

Methods

We estimated brain age in 2 studies focusing on early stages of schizophrenia or BD. In the first study, we recruited 43 participants with first episode of schizophrenia-spectrum disorders (FES) and 43 controls. In the second study, we included 96 offspring of bipolar parents (48 unaffected, 48 affected) and 60 controls. We used relevance vector regression trained on

SUBMITTER: Hajek T 

PROVIDER: S-EPMC6293219 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature