Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease.

ABSTRACT: Inflammatory bowel disease (IBD) is a complex disorder that is associated with significant morbidity. While many recent advances have been made with new diagnostic and therapeutic tools, a deeper understanding of its basic pathophysiology is needed to continue this trend toward improving treatments. By utilizing an unbiased, high-throughput transcriptomic analysis of two well-established mouse models of colitis, we set out to uncover novel coding and noncoding RNAs that are differentially expressed in the setting of colonic inflammation. RNA-seq analysis was performed using colonic tissue from two mouse models of colitis, a dextran sodium sulfate-induced model and a genetic-induced model in mice lacking IL-10. We identified 81 coding RNAs that were commonly altered in both experimental mod

SUBMITTER: Rankin CR 

PROVIDER: S-EPMC6293253 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature