Gastrodin Rescues Autistic-Like Phenotypes in Valproic Acid-Induced Animal Model.

ABSTRACT: Autism spectrum disorder (ASD) is an immensely challenging developmental disorder characterized by impaired social interaction, restricted/repetitive behavior, and anxiety. GABAergic dysfunction has been postulated to underlie these autistic symptoms. Gastrodin is widely used clinically in the treatment of neurological disorders and showed to modulate GABAergic signaling in the animal brain. The present study aimed to determine whether treatment with gastrodin can rescue valproic acid (VPA) induced autistic-like phenotypes, and to determine its possible mechanism of action. Our results showed that administration of gastrodin effectively alleviated the autistic-associated behavioral abnormalities as reflected by an increase in social interaction and decrement in repetitive/stereotyped behav

SUBMITTER: Wang X 

PROVIDER: S-EPMC6293267 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature