Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena.

ABSTRACT: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and also inflict major burdens on morbidity, quality of life, and societal costs. Considering that CVD preventive medications improve vascular outcomes in less than half of patients (often relative risk reductions range from 12% to 20% compared with placebo), precision medicine offers an attractive approach to refine the targeting of CVD medications to responsive individuals in a population and thus allocate resources more wisely and effectively. New tools furnished by advances in basic science and translational medicine could help achieve this goal. This approach could reach beyond the practitioners 'eyeball' assessment or venerable markers derived from the physical examination and standard laboratory evaluatio

SUBMITTER: Costantino S 

PROVIDER: S-EPMC6293269 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature