RNA-seq of spinal cord from nerve-injured rats after spinal cord stimulation.

ABSTRACT: Spinal cord stimulation has become an important modality in pain treatment especially for neuropathic pain conditions refractory to pharmacotherapy. However, the molecular control of inhibitory and excitatory mechanisms observed after spinal cord stimulation are poorly understood. Here, we used RNA-seq to identify differences in the expression of genes and gene networks in spinal cord tissue from nerve-injured rats with and without repetitive conventional spinal cord stimulation treatment. Five weeks after chronic constrictive injury to the left sciatic nerve, male and female rats were randomized to receive repetitive spinal cord stimulation or no treatment. Rats receiving spinal cord stimulation underwent epidural placement of a miniature stimulating electrode and received seven sessions

SUBMITTER: Stephens KE 

PROVIDER: S-EPMC6293371 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature