Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice.

ABSTRACT: Background:Animal models for neurodevelopmental disorders (NDD) generally rely on a single genetic mutation on a fixed genetic background. Recent human genetic studies however indicate that a clinical diagnosis with ASDAutism Spectrum Disorder (ASD) is almost always associated with multiple genetic fore- and background changes. The translational value of animal model studies would be greatly enhanced if genetic insults could be studied in a more quantitative framework across genetic backgrounds. Methods:We used the Collaborative Cross (CC), a novel mouse genetic reference population, to investigate the quantitative genetic architecture of mouse behavioral phenotypes commonly used in animal models for NDD. Results:Classical tests of social recognition and grooming phenotypes appeared insuff

SUBMITTER: Molenhuis RT 

PROVIDER: S-EPMC6293525 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature