Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury.

ABSTRACT:

Background

Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel management of male patients with chronic traumatic complete SCI in our centre and perform comparative analysis of the gut microbiota between our patients and healthy males.

Methods

A total of 43 male patients with chronic traumatic complete SCI (20 with quadriplegia and 23 with paraplegia) and 23 healthy male adults were enrolled. Clinical data and fresh stool specimens were collected from all participants. Face-to-face interviews were conducted to survey the neurogenic bowel management of 43 patients with SCI. Gut microbiomes were analysed by sequencing of the V3

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6293533 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature