The temporal expression patterns of brain transcriptome during chicken development and ageing.

ABSTRACT:

Background

The transcriptional profiles of mammals during brain development and ageing have been characterized. However the global expression patterns of transcriptome in the chicken brain have not been explored. Here, we systematically investigated the temporal expression profiles of lncRNAs and mRNAs across 8 stages (including 3 embryonic stages, 2 growth stages and 3 adult stages) in the female chicken cerebrum.

Results

We identified 39,907 putative lncRNAs and 14,558 mRNAs, investigated the temporal expression patterns by tracking a set of age-dependent genes and predicted potential biological functions of lncRNAs based on co-expression network. The results showed that genes with functions in development, synapses and axons exhibited a progressive decay; genes related to

SUBMITTER: Xu Z 

PROVIDER: S-EPMC6293534 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature